The comparative efficacy of a new hydrogel enterosorbent in the detoxification therapy of combined radiation-thermal lesions
Nurkhanov, B.M.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 4: 16-18
1990
ISSN/ISBN: 0031-2991 PMID: 2080077 Document Number: 349477
The detoxification effect of a new hydrogen sorbent Ikhant, synthesized on basis of piperidol homo- and copolymers, was studied on a model of combined radiation-thermal damage (CRTD). Wistar male rats were irradiated by a dose of 7.5 Gr and a IIIB degree burn was inflicted to 15% of their body surface. Intra-abdominal injection of Ikhant in the dose of 0.1 g per rat was given immediately and 24 hours after CRTD. Parallel studies of the effect of known carbon and silicon-containing sorbents on the development of toxemia in CRTD were conducted. High effectiveness of Ikhant as a measure of detoxification therapy in CRTD was established on grounds of the experimental data. By binding and discharging the toxins through the intestine, the new enterosorbent facilitates improvement of certain biochemical values of hepatic, function and, on the whole, reduces the level of the organism's autointoxication.