Autoradiographic localization of receptor sites of 3H-spiroperidol in the CNS of rat
Parízek, J.
Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove 33(1): 5-47
1990
ISSN/ISBN: 0049-5514 PMID: 2237251 Document Number: 349183
Our study presents macroautoradiographic maps of the distribution of 3H-spiroperidol in the CNS of rat. The radioactively labeled butyrophenone neurolepticum enables in vivo after brain intraventriculo-cisternal perfusion an exacter autoradiographic localization of dopamine receptors in various regions of the brain. For the first time 3H-spiroperidol has been administered by intraventriculo-cisternal perfusion. Also original are the finding of receptor labelling by means of 3H-spiroperidol on astroglia and in the spinal grey matter.