Formation of oxygenase and hydroperoxidase products by the pure reticulocyte lipoxygenase
Kühn, H.; Wiesner, R.; Schewe, T.
Biomedica Biochimica Acta 49(2-3): S39-S41
1990
ISSN/ISBN: 0232-766X PMID: 2117450 Document Number: 347898
The pure reticulocyte lipoxygenase oxygenates free arachidonic acid to 15S- and 12S-HPETE in a ratio of about 10:1 15S-H(P)ETE or its methyl ester can be further converted by the lipoxygenase via three different types of reactions: (i) oxygenase reaction, (ii) hydroperoxidase reaction and (iii) leukotriene synthase reaction. Here we summarize the products formed from arachidonic acid by the reticulocyte lipoxygenase via these three types of reactions.
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