A new cell line of rat gasserian ganglion neurinoma NGUK-1
Avtsyn, A.P.; Kondakova, L.I.; Khalanskiĭ, A.S.; Poliakova, G.P.; Chudinovskaia, N.V.
Tsitologiia 31(1): 97-102
1989
ISSN/ISBN: 0041-3771 PMID: 2718262 Document Number: 347051
A new cell line has been derived from the rat gasserian ganglion neurinoma NGUK-1 induced by transplacental administration of ethylnitrosourea. It is characterized by an astrocyte-like growth pattern at the low cell density, and by an epitheliocyte-like pattern in the confluent monolayer. The cell line displays a high proliferative activity, its maximum mitotic index and proliferative pool being--2.5 and 96%, respectively. The chromosome number ranges between 20 to 100. The chromosome modal number is 39--44. The new cell line has been used for the express diagnostic of rabies, for determination of serum glial toxicity in neurologic patients, and interferon titration.