The development of cytotoxic T lymphocytes in HLA-D/DR identity
Porubská, S.; Buc, M.; Bencová, M.; Nyulassy, S.; Stefanovic, J.
Bratislavske Lekarske Listy 90(2): 115-119
1989
ISSN/ISBN: 0006-9248 PMID: 2785838 Document Number: 346911
The development of cytotoxic T-lymphocytes is controlled by genes of the HLA complex and occurs, in the majority of cases, when the responding and stimulating subjects differ both in HLA-A, -B and HLA-D/DR antigens. We examined a married couple for kidney transplantation and found that they differed in HLA-A, -B antigens and were identical in HLA-DR antigens. The negative results of the MLC test confirmed the serological findings. Nevertheless, cytotoxic T-lymphocytes developed despite HLA-D/DR identity. The presented case is one of the few published exceptions to the rule governing the development of cytotoxic T-lymphocytes.