Stability of neuron and glial number in the abducens nerve nucleus of the ageing mouse brain
Sturrock, R.R.
Journal of Anatomy 166: 97-101
1989
ISSN/ISBN: 0021-8782 PMID: 2621150 Document Number: 346660
The number of neurons and glia in the mouse abducens nerve nucleus was estimated at 6, 25, 28 and 31 months of age. There was no significant variation in either the number of neurons (mean 118) or glia (mean 168) or in the glia to neuron ratio (mean 1.42) with age. Mean neuronal and glial nuclear diameters also remained constant and there was no obvious loss of Nissl substance and only a minimal accumulation of lipofuscin in neuronal perikarya with age. The apparent lack of age-related changes in neurons of the abducens nucleus could be a consequence of the high degree of motor activity in the extrinsic eye muscle sduring both the waking and sleeping states.