The transmembrane diffusion of trinitrine and isosorbide dinitrate. Study of artificial membranes
Guyot-Hermann, A.M.; Ringard, J.; Parier, J.L.; Lefebvre, C.; Barthelemy, C.
Annales Pharmaceutiques Francaises 47(5): 290-295
1989
ISSN/ISBN: 0003-4509 PMID: 2517772 Document Number: 346636
Nitroglycerin pharmacodynamic efficiency is 3 to 4 times higher than isosorbide dinitrate efficiency. Data of this study on physiological and artificial membranes point the greater nitroglycerin transmembrane diffusion, which is discussed as a possible relevant explanation.
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