Effect of isosorbide dinitrate on non-cirrhotic portal hypertension
Roy, D.G.; Kaur, U.; Chawla, Y.K.; Singh, K.; Dilawari, J.B.
National Medical Journal of India 4(1): 5-9
1991
ISSN/ISBN: 0970-258X PMID: 29751471 Document Number: 369404
Among the many drugs including propranolol that have been evaluated for the pharmacological control of portal hypertension, isosorbide dinitrate (ISDN) fulfils the criteria of patient acceptability, ease of administration and production of the desired effect. Forty-three consecutive patients with uncomplicated noncirrhotic portal hypertension (NCPH) caused by extrahepatic portal venous obstruction (EHO=32) and non-cirrhotic portal fibrosis (NCPF=l1) were given 20 mg of ISDN sublingually and in the supine position the intrasplenic pulp pressure (ISPP) was monitored for 10 minutes. The fall in mean ISPP became significant at 4 minutes in patients with EHO (p