A comparative study of the metabolic effects of injectable and oral contraceptives
Liew, D.F.; Ng, C.S.; Heng, S.H.; Ratnam, S.S.
Contraception 33(4): 385-394
1986
ISSN/ISBN: 0010-7824 PMID: 2942334 DOI: 10.1016/0010-7824(86)90101-0Document Number: 346259
The metabolic effects of an injectable contraceptive, Depo-provera (medroxyprogesterone acetate), an oral contraceptive pill containing 50 ug ethinyl estradiol and 500 ug norgestrel and a control group (not on contraceptives) were compared in 3 groups, each comprising 32 women. The subjects were matched for race, age and parity. Mean duration of treatment was 41.7 .+-. 18.3 months for Depo-provera and 59.6 .+-. 29.0 months for the pill group. Glucose tolerance was impaired in both treatment groups. The combination pill showed more changes in both glucose tolerance and insulin response. Lipid levels remained unchanged in both treatment groups.