Metabolic effects of once-a-month combined injectable contraceptives

Giwa Osagie, O.F.; Regulation, T.W.o Task Force, O.L.ng Acting Systemic Agents For Fertility

Contraception 49(5): 421-433

1994


ISSN/ISBN: 0010-7824
DOI: 10.1016/0010-7824(94)90001-9
Document Number: 285988
The results of metabolic studies on once-a-month combined injectable contraceptives are summarized, focusing on four preparations: dihydroxyprogesterone acetophenide 150 mg/estradiol enanthate 10 mg; depot-medroxyprogesterone acetate 25 mg/estradiol cypionate 5 mg; norethisterone enanthate 50 mg/estradiol valerate 5 mg; and 17-beta-hydroxyprogesterone caproate 250 mg/estradiol valerate 5 mg. Their effects on carbohydrate metabolism, lipid metabolism, hemostasis, serum prolactin, cortisol, binding globulins and liver functions are reviewed. Areas requiring further research are identified.

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