Effect of maltose tetrapalmitate on tumor vascularization and tumor growth
Benrezzak, O.; Bissonnette, E.; Madarnas, P.; Nigam, V.N.
Anticancer Research 9(6): 1815-1818
1989
ISSN/ISBN: 0250-7005 PMID: 2483306 Document Number: 345878
C3HBA mammary tumor (H-2k) was implanted s.c. by trocar in MTP responder C3H/HeN (N-2k) and non-responder C3H/HeJ (H-2k) female mice. One half of the animals received MTP i.p. The size of the tumor was measured everyday. Tumor growth was slightly slower in the C3H/HeJ than in the C3H/HeN. MTP treatment was effective only for the tumor implanted in the C3H/HeN. Macroscopic and microscopic visualization of the tumor 1, 2, 3, and 15 days after tumor implantation and MTP treatment revealed poor vascular development in the MTP-treated C3H/HeN compared to untreated controls at days 2 and 3.