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The effect of antibody against vascular endothelial growth factor on tumor growth

Wang, G.; Wang, N.; Liu, T.

Zhonghua Zhong Liu Za Zhi 19(3): 163-166

1997

ISSN/ISBN: 0253-3766
PMID: 10920886
Document Number: 479057
Objective: Vascular endothelial growth factor (VEGF) is a very important factor in the process of angiogenesis, which is chosen as a target for experimental study of anticancer. Methods: Anti-VEGF antibody was obtained from immunized rabbits and purified with affinity column. Morever, it was identified as neutralized antibody by Mile's assay. Results: The anti-VEGF antibody was able to inhibit growth of S180 sarcoma in a dose-dependent manner, and the inhibition rate reached 41.0% with dose 200 mu-g per mouse per day. For human gastric cancer (MGC-803)-bearing nude mice, Anti-VEGF antibody inhibited tumor growth by 76.2%. When anti-VEGF antibody was combined with 131I-3H11, a murine monclonal antibody conjugated with 131I for treatment, only one of five nude mice developed tumor and 84.0% more inhibition of tumor growth was obtained in comparison with treatment by 131I-3H11 only. Conclusion: The anti-VEGF antibody may be potentially useful for clinical treatment of cancer.

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