Primary dapsone resistance as assessed by uptake of labelled thymidine by the macrophage resident Mycobacterium leprae
Thakur, M.; Vaishnavi, C.; Ganguly, N.K.; Kaur, S.; Kumar, B.
Indian Journal of Leprosy 61(4): 437-441
1989
ISSN/ISBN: 0254-9395 PMID: 2695575 Document Number: 345709
12 untreated lepromatous leprosy patients were screened for primary dapsone resistance by the uptake of labelled thymidine by macrophage resident M. leprae. There were found to harbour primary dapsone resistant strains of M. leprae and another three partially resistant strains to the drug. This rapid, simple and reliable method should be used routinely to screen leprosy patients, for drug resistance.