Activity of the combination of isoniazid, protionamide and dapsone against Mycobacterium leprae and some other mycobacteria
Pattyn, S.R.; Portaels, F.; Van Loo, G.; Van den Breen, L.
Arzneimittel-Forschung 31(12): 2155-2157
1981
ISSN/ISBN: 0004-4172 PMID: 7037011 Document Number: 168487
No additive effect was found at the addition of isoniazid to either dapsone or protionamide against M. leprae and against highly dapsone-sensitive in vitro growing Mycobacterium sp. strains. It is concluded that the indication of the administration of isoniazid in leprosy is extremely limited and could only be envisaged as a companion drug in combined therapy of dapsone-resistant multibacillary leprosy in light-skinned people, when aminoglycosides cannot be administered.