Transient Parkinson syndrome and tremor caused by the use of sodium valproate
Van der Zwan, A.
Nederlands Tijdschrift Voor Geneeskunde 133(24): 1230-1232
1989
ISSN/ISBN: 0028-2162 PMID: 2501690 Document Number: 345609
From 1986 till 1988, 88 patients received sodium valproate for the first time as a therapy for epilepsy. One of them developed a fine tremor, three a coarse tremor with a cogwheel phenomenon, two developed a full parkinsonian syndrome. All these symptoms in these six patients disappeared completely or nearly completely after changing to another anti-epileptic drug or reducing the dose.