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The PM-Scl (polymyositis-scleroderma) autoantibody and its nucleolar fluorescence pattern

Kühn, G.; Jarzabek-Chorzelska, M.; Blaszczyk, M.; Kolacinska-Strasz, Z.; Chorzelski, T.P.; Jablonska, S.

Dermatologische Monatschrift 175(8): 479-483

1989

ISSN/ISBN: 0011-9083
PMID: 2676628
Document Number: 345544
By indirect immunofluorescence studies of antinuclear antibodies on hamster liver imprints as a substrate performed to determine the nuclear staining pattern of sera from patients with connective tissue diseases 10 sera showed a distinct homogeneous nucleolar staining pattern associated with weaker speckled or homogeneous nucleoplasmic fluorescence. In all 10 cases the antibodies revealed the PM-Scl specificity in immunodiffusion. Clinically 9 patients had an acrosclerosis, in 56% overlapped with symptoms of polymyositis. Only one patient had a diffuse scleroderma. The homogeneous nucleolar immunofluorescence pattern of PM-Scl should be distinguished from mixed nucleolar and diffuse reticular nucleoplasmic pattern of Scl-70.

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