Preparation of peroral delayed-action drug forms using biological polymers as the base. 4. Preparation of erosion tablets with a base of starch hydrolysis products
Mank, R.; Kala, H.; Lorenz, A.
Die Pharmazie 44(9): 617-618
1989
ISSN/ISBN: 0031-7144 PMID: 2608707 Document Number: 345332
The preparation and investigation of erosonic tablets using a modified starch product are described. Codeine phosphate and pholedrine sulfate served as model drugs. The pharmaceutical investigations showed, that this product is a good auxiliary substance for the direct compression. When in contact with water, the tablets form a gel. This gel determines the drug release. In in vitro investigations a degradation of the starch product by enzymes was detected. Especially the amount of the release values obtained were analyzed by the equation of Noyes-Whitney.