The effect of gamma rays on medazepam in a methanolic solution
Werner, I.A.; Altorfer, H.; Perlia, X.
Pharmaceutica Acta Helvetiae 64(4): 98-115
1989
ISSN/ISBN: 0031-6865 PMID: 2567015 Document Number: 344055
Nine radiolytical products have been identified in a methanolic solution of Medazepam exposed to gamma-irradiation. A decomposition model taking into account these radiolytical products is presented. The formation of the individual radiolytical products can be deduced from analogous reactions of the radicals e-sdv., H, CH2OH, OH and HO2/O2- with several substances. Based on this knowledge of the radiochemical behaviour of Medazepam scavenger systems against radiolysis in solution can be developped.