Activity of topical flunoxaprofen in nonspecific vaginitis. Comparison with meclocycline sulfosalicylate
Facchini, V.; Rispoli, G.; Dubini, F.; Bignami, P.; Sacchi, C.
Minerva Ginecologica 41(12): 609-614
1989
ISSN/ISBN: 0026-4784 PMID: 2626206 Document Number: 344033
A trial was performed in 30 patients affected by non-specific vaginitis. The results show that the topical application (by vaginal washings) of flunoxaprofen produces a high therapeutic activity like that of meclocycline. Contrary to meclocycline, flunoxaprofen does not possess bactericidal and bacteriostatic properties. Therefore, the normalization of vaginal flora, with a remarkable increase of Döderlein bacillus, is exclusively due to local antiphlogistic activity of flunoxaprofen. Contrary to meclocycline, flunoxaprofen induces a precocious increase of Döderlein bacillus, necessary for a definitive normalization and to limit the possibility of relapses.