Exacerbation of metastatic disease shortly after administration of tamoxifen in ER negative advanced breast carcinoma. A case report
Cocconi, G.; Boni, C.; Naldi, N.; Nizzoli, R.; Bozzetti, C.
Tumori 75(6): 566-569
1989
ISSN/ISBN: 0300-8916 PMID: 2617702 Document Number: 343508
In a patient with long untreated slow-growing osteoblastic bone metastases from an ER/PgR negative brest carcinoma, new metastatic sites in many lymphonodes pleura and massively in liver have been observed 4 weeks after receiving tamoxifen. Cause-effect relationship between administration of the drug and this unusually rapid spreading of the disease may be considered only as a hypothesis, as it is based wholly on clinical outcome. However, reporting of any exacerbation of breast cancer apparently induced by tamoxifen, even if only anecdotal, is advisable.