A case of recurrent breast cancer responding to long-term administration of tamoxifen
Yayoi, E.; Kobayashi, T.; Inaji, H.; Maeura, Y.; Mori, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 11(8): 1683-1686
1984
ISSN/ISBN: 0385-0684 PMID: 6433801 Document Number: 239485
A 44-year-old premenopausal woman with metastatic breast cancer to the bones was treated with tamoxifen and tegafur followed by a minimal dose of tamoxifen alone, with complete response for more than 90 months. Initially, tamoxifen was given with a dose of 20 mg daily in combination with 600 mg daily of tegafur for 22 months, a remission of low back pain and recalcification of the lytic lesion in the pelvis. After reduction of tamoxifen dose to 10 mg/daily and withdrawal of tegafur, regression of the disease continued for another 68+ months. Bone metastasis completely disappeared, and the patient is still in remission. No significant side effects from tamoxifen were encountered. Tamoxifen appears to be a useful and safe treatment for recurrent breast cancer.