The cAMP content and cAMP-dependent protein kinase activity in the brain of rabbits in the dynamics of moderate craniocerebral trauma

Kucherenko, S.N.; Ostapenko, L.I.; Vasil'ev, A.N.

Biulleten' Eksperimental'noi Biologii i Meditsiny 107(4): 433-435

1989


ISSN/ISBN: 0365-9615
PMID: 2541831
Document Number: 343302
An intracellular concentration of cAMP is a factor to define activity of cAMP-dependent protein kinases. Enzyme activity changes in cytosol and microsomal fractions from investigated brain's regions. Two-phase character of posttraumatic changes of A-kinases activity is shown. Linear dependence for microsomal fractions obtained from brain's hemispheres is observed between A-kinases activity and calculated equilibrium cAMP concentration in different time after experimental cranial trauma.

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