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Reversible pancytopenia following OKT3. Use in the context of multidrug immunosuppression for kidney allografting

Burke, G.W.; Vercellotti, G.M.; Simmons, R.L.; Howe, R.B.; Canafax, D.M.; Najarian, J.S.

Transplantation 48(3): 403-408

1989

ISSN/ISBN: 0041-1337
PMID: 2528849
Document Number: 342365
We present two instances of pancytopenia in kidney transplant patients associated with a course of OKT3 therapy. In one case, OKT3 was used prophylactically, in the other therapeutically to treat biopsy-proved rejection. They both occurred in the setting of multi-drug immunosuppression, including Minnesota anti-lymphyocyte globulin, and recovered with supportive therapy. Previous antihypertensive medication, antibiotics, and azathioprine were restarted without hematologic sequelae. Evidence implicating OKT3, and resultant gamma-interferon-induced marrow suppression is discussed.

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