Preoperative immunosuppression in the kidney-transplanted dog in connection with specific antigenic pre-treatment
Harder, F.; Claudi, B.; Mihatsch, M.; Floersheim, G.L.
Helvetica Chirurgica Acta 45(1-2): 161-165
1978
ISSN/ISBN: 0018-0181 PMID: 350811 Document Number: 132593
Postoperative, nonspecific routine immunosuppressive therapy fails in up to 50% in human cadaver renal transplantation. Donorspecific preoperative immunological conditioning of the host is harder to induce in dogs than in some rodents. In a pilot study 2 i.v. donorblood injections on days -18 and -11 followed by a 6-day preoperative pulse without any postoperative therapy induce a significant albeit limited prolongation of graft function.