IgG subclass responses to a transmembrane protein (gp41) peptide in HIV infection
Chiodi, F.; Mathiesen, T.; Albert, J.; Parks, E.; Norrby, E.; Wahren, B.
Journal of Immunology 142(11): 3809-3814
1989
ISSN/ISBN: 0022-1767 PMID: 2497181 Document Number: 341568
The IgG subclass distribution to the E34/E32 peptides, derived from the HIV-1 glycoprotein 41 transmembrane protein, was analyzed in ELISA. Sera from individuals at different stages of the disease were assayed. A restricted subclass response of mainly IgG1 and IgG2 was found. The subclass response was of a different type than the one observed to HIV whole Ag and to a synthetic peptide from the C'-terminal part of the HIV-1 p24 core protein. An increased subclass restriction was observed in progressed stages of the disease.