Protein composition of blood serum and the products of nitrogen metabolism in humans during long-term hypokinesia
Zaitseva, L.B.; Larina, O.N.; Popova, I.A.
Kosmicheskaia Biologiia i Aviakosmicheskaia Meditsina 23(5): 50-54
1989
ISSN/ISBN: 0321-5040 PMID: 2480473 Document Number: 341055
Examination of 9 healthy young men exposed to antiorthostatic hypokinesia (-5.degree.) for 370 days revealed enhanced catabolic processes in the muscular tissue. This manifested as increases of creatinine in blood and urine as well as of the creatinine coefficient. The use of countermeasures prior to experimental day 170 helped to maintain the concentration of final nitrogen metabolites at the baseline level. The serum concentrations of total protein and protein fractions remained within the normal limits and varied in a phasic manner. We observed a decrease of the concentration of .alpha.2-globulins, which indicates inhibition of the synthetic activity of the liver, and an increase of that of .beta.-globulins, which suggests an adverse effect of head-down tilt on lipid metabolism.