Reduced locomotor activity of rats made histidinemic by injection of histidine
Dutra-Filho, C.S.; Wannmacher, C.M.; Pires, R.F.; Gus, G.; Kalil, A.M.; Wajner, M.
Journal of Nutrition 119(8): 1223-1227
1989
ISSN/ISBN: 0022-3166 PMID: 2778547 Document Number: 340493
Acute histidinemia was provoked in 30-d-old male Wistar rats by injecting intraperitoneally either histidine alone (0.5 mg/g body wt) or histidine (0.25 mg/g body wt) plus the histidase inhibitor nitromethane (0.73 mg/g body wt). Histidase activity was approximately 90% inhibited in rats receiving nitromethane. Serum histidine in both groups reached levels similar to those of histidinemic patients. Rats were subjected to the open field behavioral task, and the numbe rof rearings and crossings were counted. A consistently lower locomotor activity was observed in the histidinemic rats. It is proposed that reduced locomotor activity and its relationship to psychomotor development should be investigated in histidinemic children.