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Characterization of a plasmid coding for resistance to broad-spectrum cephalosporins in Salmonella typhimurium

Garbarg-Chenon, A.; Vu Thien, H.; Labia, R.; Ben-Yaghlane, H.; Godard, V.; Deny, P.; Bricout, F.; Nicolas, J.C.

Drugs under Experimental and Clinical Research 15(4): 145-150

1989

ISSN/ISBN: 0378-6501
PMID: 2673714
Document Number: 340187
Five strains of Salmonella typhimurium isolated from faeces of infants hospitalized at Trousseau Hospital in Paris have been found to be resistant to third-generation cephalosporins. This resistance is by a transferable plasmid-mediated mechanism. The beta-lactamase gene which encodes for an enzyme similar to SHV-2 has been cloned into plasmid pBR322 and expressed in Escherichia coli RR1.

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