Antigenic specificity of neuraminidase and structure of neuraminidase gene of influenza A (H1N1) serotype Hsw1N1 viruses isolated from man and animals
Chuvakova, Z.K.; Dem'ianenko, I.V.; Chaĭka, O.V.; Shilov, A.A.; Kim, E.V.; Rovnova, Z.I.; Isaeva, E.I.; Isaeva, E.S.
Voprosy Virusologii 34(6): 656-661
1989
ISSN/ISBN: 0507-4088 PMID: 2483778 Document Number: 338597
The enzyme immunoassay and neuraminidase activity inhibition test using polyclonal and monospecific antineuraminidase sera were employed to establish the similarities and differences in the antigenic structure of neuraminidase of influenza A viruses (H1N1), serovariant Hsw1N1, isolated from man in Alma-Ata (USSR), 1984, New Jersey (USA), 1976, and Pazardjik (BPR), 1982, as well as from swine and birds. Oligonucleotide mapping revealed significant structural differences in the genes coding for neuraminidase of Hsw1N1 viruses. The experimental results indicate a high degree of the enzyme variability in this group of viruses.