Top Abstract Purchase Related
Home
>
Node
>
Subnode

Sedative and analgesic effects of medetomidine in dogs--an open clinical study

Nilsfors, L.; Garmer, L.; Adolfsson, A.

Acta Veterinaria Scandinavica. Supplementum 85: 155-159

1989

ISSN/ISBN: 0065-1699
PMID: 2571267
Document Number: 337746
Medetomidine was given parenterally as a sedative and analgesic agent to 283 dogs. Mean doses varied from 17 micrograms/kg for x-ray examinations to 31 micrograms/kg for clinical examinations. An adequate analgesic effect was demonstrated at higher doses than produced sufficient sedation. Potent bradycardia was produced within 15 minutes post administration. No influence of breed, sex or age was found. Vomiting was observed in 8% of the cases. One dog died, showing chronic glomerulonephritis, myocardial necrosis and liver congestion at autopsy.

Document emailed within 1 workday
Secure & encrypted payments

Lascelles, B.D.; Butterworth, S.J.; Waterman, A.E. 1994: Postoperative analgesic and sedative effects of carprofen and pethidine in dogs Veterinary Record 134(8): 187-191
Bryant, C.E.; England, G.C.; Clarke, K.W. 1991: Comparison of the sedative effects of medetomidine and xylazine in horses Veterinary Record 129(19): 421-423
Pypendop, B.; Serteyn, D.; Verstegen, J. 1996: Hemodynamic effects of medetomidine-midazolam-butorphanol and medetomidine-midazolam-buprenorphine combinations and reversibility by atipamezole in dogs American Journal of Veterinary Research 57(5): 724-730
Xu, D.Y.; Yang, D.L.; Ding, Y.S.; Deng, P. 1986: The sedative, antipyretic and analgesic effects of betaine hydrochloride Yao Xue Xue Bao 21(1): 61-64
Lombard, C.W.; Kvart, C.; Sateri, H.; Holm, G.; Nilsfors, L. 1989: Effects of medetomidine in dogs with mitral regurgitation Acta Veterinaria Scandinavica. Supplementum 85: 167-174
Nolan, A.; Reid, J. 1993: Comparison of the postoperative analgesic and sedative effects of carprofen and papaveretum in the dog Veterinary Record 133(10): 240-242
Lester, P.A.; Gaynor, J.S.; Hellyer, P.W.; Mama, K.; Wagner, A.E. 2003: The sedative and behavioral effects of nalbuphine in dogs Contemporary Topics in Laboratory Animal Science 42(4): 27-31
Newell, S.M.; Ko, J.C.; Ginn, P.E.; Heaton-Jones, T.G.; Hyatt, D.A.; Cardwell, A.L.; Mauragis, D.F.; Harrison, J.M. 1997: Effects of three sedative protocols on glomerular filtration rate in clinically normal dogs American Journal of Veterinary Research 58(5): 446-450
Cohen, A.T. 1987: Experience with alfentanil infusion as an intensive care sedative analgesic European Journal of Anaesthesiology. Suppl 1: 63-66
Adams, H.A.; Biscoping, J.; Russ, W.; Bachmann, B.; Ratthey, K.; Hempelmann, G. 1988: Sedative-analgesic medication in intensive care patients needing ventilator treatment Der Anaesthesist 37(4): 268-276
Longo, F.N.; Potortì, F.; Urbano, O.; Perroni, G.B. 1988: Effects of buflomedil on peripheral arteriopathies. An open clinical study Minerva Cardioangiologica 36(5): 249-252
Guo, J.; Duan, J.-a.; Tang, Y.; Jia, N.; Li, X.; Zhang, J. 2010: Fast onset of action and the analgesic and sedative efficacy of essential oil from Rhizoma Chuanxiong after nasal administration Die Pharmazie 65(4): 296-299
Sap, R.; Hellebrekers, L.J.; van Foreest, A.W.; ter Beek, F.J. 1997: Veterinary dentistry (13). Evaluation of the use of medetomidine and ketamine to induce anaesthesia in dogs undergoing dental surgery Tijdschrift Voor Diergeneeskunde 122(11): 309-312
Gerbig, T. 1979: Azaperone (Stresnil) as a sedative for dogs Berliner und Münchener Tierärztliche Wochenschrift 92(1): 12-15
Such, L.; Morcillo, E.; Chorro, F.J.; Montoro, A.; Alberola, A.; Aparicio, F.; Viña, J. 1986: Beneficial effects of N-acetyl cysteine on acute myocardial infarction in open-chest dogs Archivos de Farmacologia y Toxicologia 12(1): 37-40
Scheinin, H.; Kallio, A.; Koulu, M.; Scheinin, M. 1989: Pharmacological effects of medetomidine in humans Acta Veterinaria Scandinavica. Supplementum 85: 145-147
De Castro, J.; Van de Water, A.; Wouters, L.; Xhonneux, R.; Reneman, R.; Kay, B. 1979: Comparative study of cardiovascular, neurological and metabolic side effects of 8 narcotics in dogs. Pethidine, piritramide, morphine, phenoperidine, fentanyl, R 39 209, sufentanil, R 34 995. II. Comparative study on the epileptoid activity of the narcotics used in high and massive doses in curarised and mechanically ventilated dogs Acta Anaesthesiologica Belgica 30(1): 55-69
Meng, Q.-Y.; Huang, H.-M.; Xu, H. 2019: The sedative effect of dexmedetomidine in outpatient undergoing dental surgery compared to several sedative drugs:a meta analysis Shanghai Kou Qiang Yi Xue 28(1): 100-109
Fischer, G.; Schneider, W.; Krumpl, G.; Grohs, J.G.; Raberger, G. 1989: Effects of niguldipine, a new dihydropyridine calcium antagonist, on regional blood flow, cardiac performance and myocardial metabolism in anaesthetized open-chest dogs Archives Internationales de Pharmacodynamie et de Therapie 298: 96-107
Shankar, N.; Varshney, A.; Bhattacharya, A.; Sharma, K.N. 1996: Electroacupuncture, morphine and clonidine: a comparative study of analgesic effects Indian Journal of Physiology and Pharmacology 40(3): 225-230