The sedative, antipyretic and analgesic effects of betaine hydrochloride
Xu, D.Y.; Yang, D.L.; Ding, Y.S.; Deng, P.
Yao Xue Xue Bao 21(1): 61-64
1986
ISSN/ISBN: 0513-4870 PMID: 3487915 Document Number: 282791
When betaine hydrochloride was given orally 250 .apprx. 1000 mg/kg, the motor activity of mice was reduced 50 .apprx. 81%. The hypnotic effect of pentobarbital was markedly increased after oral administration of betaine hydrochloride at the dosage of 500 mg/kg or 1000 mg/kg. Analgesic effect of betaine was demonstrated in mice by the hot plate method (55.degree. C) and the acetic and writhing test when given intraperitoneally at the dosage of 540 mg/kg or 900 mg/kg. The analgesic effect of betaine (500 mg/kg) was antagonized by prior administration of atropine (5 mg/kg). Betaine hydrochloride (500 mg/kg) given by gastric intubation was shown to have antipyretic effect in rabbits with iv TAB vaccine fever, but not in normothermic rabbits.