Decline in cycling of granulocyte-macrophage colony-forming cells with increasing age in mice
Tejero, C.; Testa, N.G.; Hendry, J.H.
Experimental Hematology 17(1): 66-67
1989
ISSN/ISBN: 0301-472X PMID: 2908863 Document Number: 337596
The cycling state of granulocyte-macrophage progenitor cells (GM-CFC) was measured using the [3H]thymidine suicide technique in individual male B6D2F1 mice. The proportion of the GM-CFC population in S phase was found to decrease from 25%-35% at 1-6 months of age to about 10% in mice greater than 2 years old.
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