Metabolic activation of polycyclic aromatic hydrocarbons to mutagens in the Ames test by various animal species including man
Phillipson, C.E.; Ioannides, C.
Mutation Research 211(1): 147-151
1989
ISSN/ISBN: 0027-5107 PMID: 2493576 Document Number: 336442
6 polycyclic aromatic hydrocarbons were assayed for mutagenicity in the Ames test, in the presence of hepatic post-mitochondrial preparations isolated from the mouse, rat, hamster, pig and man. Benzoanthracene was not activated by any of the hepatic preparations. It is concluded that, among the animal species studied the hamster is generally the most efficient in activating polycyclic aromatic hydrocarbons to mutagens in the Ames test.