Establishing the structure of anthracyclinones produced by Streptomyces griseoruber
Bakina, E.V.; Iartseva, I.V.; Povarov, L.S.; Aleksandrova, L.G.; Tulemisova, K.A.; Mamonova, L.P.; Preobrazhenskaia, M.N.
Bioorganicheskaia Khimiia 15(10): 1423-1430
1989
ISSN/ISBN: 0132-3423 PMID: 2631686 Document Number: 335812
Streptomyces grisoruber strain 1618-306 produces three types of anthracycline antibiotics, derivatives of epsilon-pyrromycinone (methyl (7S, 9R, 10R)-9-ethyl-5,7,8,9,10,12-hexahydro-1,4,6,7,9-pentahydroxy-5,12-di oxo-10- naphthacenecarboxylate), epsilon-1-hydroxyauramycinone and epsilon-1-hydroxysulfurmycinone, differing in C-9 substituent in D ring of anthracyclines (Et, Met or CH2COCH3, respectively). Besides 7-O-glycosides of these aglycones, complex of antibiotics contains corresponding 7-deoxy- and 7,8,9,10-bisanhydroanthracyclinones.