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Evaluation of nickel complexes of bioligands-effect on distribution profile

Srivastava, R.C.; Srivastava, S.K.; Gupta, S.; Athar, M.; Hasan, S.K.

Research Communications in Chemical Pathology and Pharmacology 65(2): 253-256

1989

ISSN/ISBN: 0034-5164
PMID: 2587843
Document Number: 335685
Distribution of various nickel-63 bioligand complexes in tissues of rats and their binding to subcellular fractions have been studied. Nickel-binding with glutathione and histidine significantly decreased nickel-63 accumulation while nickel-serum binding increased nickel body burden and its accumulation is subcellular fractions. Nickel-renal cytosol binding exhibited distribution pattern similar to serum complex only in lung tissue.

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