The Effect of Physical Form of Implant on Nickel Sulphide Tumourigenesis in the Rat
Gilman, J.P.; Herchen, H.
Acta - Unio Internationalis Contra Cancrum 19: 615-619
1963
ISSN/ISBN: 0365-3056 PMID: 14050619 Document Number: 3186
Groups of rats were exposed to single intramuscular implantations of nickel sulphide (Ni3S2) as free powder, powder contained in diffusion chambers, chips and discs. These differences in physical form had no significant effect on tumour incidence, which ranged from 71 to 95 percent. However, the average latent period was almost doubled when the carcinogen was contained in diffusion chambers. Tumours were all locally occurring rhabdomyosarcomas and exhibited a high incidence of metastases. It was shown that neither the walling off of the metal implants nor phagocytosis nor direct contact between metal particles and cell are necessary to the mechanism of tumorigenesis with nickel or cobalt compounds.
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