The myoelectrical activity of the gastroduodenal area in ulcer formation due to serotonin
Shemerovskiĭ, K.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 108(9): 285-287
1989
ISSN/ISBN: 0365-9615 PMID: 2611384 Document Number: 335579
The effects of prolonged subcutaneous administration of serotonin on the myoelectric activity of the gastroduodenal junction were investigated in conscious rabbits. Serotonin produced the duodenogastric discoordination by increasing duodenal activity and decreasing the activity of stomach and pylorus. This discoordination resulted in gastric ulceration. Atropine prevented both duodenogastric discoordination and ulceration. These results indicate that serotonin ulceration is related to duodenogastric discoordination.