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Onset and duration of clinical relaxation of atracurium and vecuronium in patients on chronic nifedipine therapy

Bell, P.F.; Mirakhur, R.K.; Elliott, P.

European Journal of Anaesthesiology 6(5): 343-346

1989

ISSN/ISBN: 0265-0215
PMID: 2571501
Document Number: 335481
The onset and duration of clinical relaxation of atracurium and vecuronium were studied in patients on chronic nifedipine therapy and compared to similar groups of patients not on such a therapy. Neuromuscular block was monitored by recording the integrated electromyogram of the hypothenar muscles (using a 'Datex Relaxograph') following stimulation of the ulnar nerve with a train-of-four stimulation. Neither the time to onset of maximum block (3.0-3.4 min) nor the duration of clinical relaxation (36-40 min) differed significantly between the groups indicating no significant interaction in humans between atracurium and vecuronium and chronic nifedipine therapy.

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