Hepatitis B virus: DNA integration and hepatocellular carcinoma
Matsubara, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 16(3 Part 2): 530-541
1989
ISSN/ISBN: 0385-0684 PMID: 2539782 Document Number: 335395
Hepatitis B Virus DNA integrates into host cell DNA upon infection. Analyses of early integrants have revealed that the origin of DNA synthesis in the viral genome plays a major role in the integration process. In liver cancers many of the integrants are found in different structures, suggesting that the primary integrants must have undergone secondary rearrangements. Such rearrangements include large deletions, translocations, inversions, and local amplifications. The mechanism that leads to these rearrangements are inferred, and their role in development of hepatocellular carcinomas is discussed.