Functional biochemical changes and their pharmacologic correction by pirroksan in renal ischemia
Shepotinovskiĭ, V.I.; Mikashinovich, Z.I.; Shapiro, G.A.; Ivanova, O.V.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1989(4): 24-27
1989
ISSN/ISBN: 0031-2991 PMID: 2574439 Document Number: 335324
Bilateral one-hour ischemia of the kidneys in rats causes essential metabolic shifts in the renal tissues, and diminished intensity of the energetic status as a result of which the intactness of the cell membranes and the main functions of the nephron are disturbed. Pharmacological correction of postischemic disorders by the alpha-adrenergic blocking agent pyrroxane increases the activity of oxidative processes and intensifies the glycolysis rate. Improvement of the energy provision of the nephron function occurs in parallel with restoration of the diuresis level and processes of filtration and reabsorption.