Morphological changes of hemomicrocirculatory bed of the organs of rat masticatory apparatus after the exposure to general vibration and during pharmacologic correction
Gaĭvoronskiĭ, I.V.; Iordanishvili, A.K.; Kovalevskiĭ, A.M.
Morfologiia 144(6): 36-40
2013
ISSN/ISBN: 1026-3543 PMID: 24707738 Document Number: 670280
The effect of chronic exposure to general vibration on the state of hemomicrocirculatory bed in the organs of rat masticatory apparatus and the efficacy of antihypoxants and adaptogens for its pharmacological prophylaxis was studied. The experiments were performed in 210 albino male rats aged 8 to 30 weeks. The intact rats served as control. Transcapillary injections with 1% collargol solution, histological, electron microscopic and morphometric methods were used. It was found that chronic exposure to general vibration induced a hemodynamic disturbances at the level of hemomicrocirculatory bed vessels in the organs of masticatory apparatus with subsequent hypoxia. Electron microscopic study revealed the damage of the cellular ultrastructure in the endotheliocytes of blood vessels of the hemomicrocirculatory bed. Antihypoxants, adaptogens and their combinations demonstrated a pronounced protective effect