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Pharmacokinetics of intravenous enoximone in dialysis patients

Fiegel, P.; Trenk, D.; Jaehnchen, E.; Dieterich, H.A.

Journal of Cardiovascular Pharmacology 14(Suppl 1): S20-S23

1989

ISSN/ISBN: 0160-2446
PMID: 2480479
Document Number: 334792
The study was carried out using 140 rabbits adapted to different altitudes (1000 m, 2000 m and 3250 m above sea level) for various times (from 2 days to 2 months). In the course of adaptation to high altitude hypoxia immediate adaptive changes (systemic, central hemodynamics, coronary circulation, cardiac electrical stability) and profound structural changes that formed the foundation of long-term adaptation (metabolic and structural changes) developed. The degree of adaptive changes was correlated with the altitude and time of exposure to hypoxia. High mountain adaptation developed in stages to sustain body requirements.

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