Pharmacokinetics of intravenous propafenone in patients with episodes of paroxysmal supraventricular tachycardia
Arboix, M.; Puigdemont, A.; Moya, A.; Cinca, J.
Methods and Findings in Experimental and Clinical Pharmacology 7(8): 435-438
1985
ISSN/ISBN: 0379-0355 PMID: 4079594 Document Number: 244134
The plasma concentration time curves of propafenone after administration of single i.v. (2.3 .+-. 0.2 mg/kg) doses have been studied in ten patients undergoing an electrophysiological study to evaluate episodes of recurrent supraventricular tachycardia. The propafenone kinetics profile can be described by a two-compartment open model. Mean values of main variables were t1/2.alpha. = 2.8 min, t1/2.beta. = 80 min, Kel = 0.12 min-1, Vd.beta. = 1.6 l/kg, Cl = 1.03 l/h and AUR = 3.1 mg/h-1.