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Immunoenzyme analysis with corpuscular antigen in the study of zoonotic cutaneous leishmaniasis

Goncharov, D.B.; Gracheva, L.I.; Saf'ianova, V.M.; Dobrzhanskaia, R.S.; Khuseĭinova, K.K.

Meditsinskaia Parazitologiia i Parazitarnye Bolezni 6: 31-35

1989

ISSN/ISBN: 0025-8326
PMID: 2697793
Document Number: 333387
Comparative study of sera from patients suffering from zoonotic cutaneous leishmaniasis by indirect immunofluorescence (IIF) and by enzyme immunoassay (ELISA) gave 72.4 and 89.6% positive results, correspondingly, with homologous antigen L. major. Good correlation of these methods was revealed--coincidence in 83% cases. Authors used ELISA with corpuscular Leishmania antigen. The test was superior to IIF in sensitivity and specificity. Creation of type-specific Leishmania test systems for ELISA opens new vistas in studies of the population immune structure in combined zoonotic cutaneous leishmaniasis and visceral leishmaniasis foci.

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