Production of antibiotic substances by natural variants of the marine bacterium Vibrio Fischeri
Baranova, N.A.; Egorov, N.S.
Antibiotiki i Khimioterapiia 34(1): 7-10
1989
ISSN/ISBN: 0235-2990 PMID: 2730220 Document Number: 333034
It was shown that under definite conditions there was competition between natural variants of sea bacteria belonging to V. fischeri. Natural variants of V. fischeri, strain 6 differed in their resistance to streptomycin and had different growth rates under conditions of limited aeration. Morphologically all the variants were identical. V. fischeri P-0, V. fischeri P-I and V. fischeri P-2 were studied. The study revealed that V. fischeri P-0 produced a non-dialysing thermostable trypsine-sensitive substance inhibiting the growth of V. fischeri P-1 and V. fischeri P-2. The maxumum activity of the antibacterial substance was observed when V. fischeri P-0 was grown in a liquid medium with peptone and yeast extract without agitation at 26.degree.C. The inhibiting substance was also active against V. fischeri BKM B995 and V. fischeri P-7 isolated as a result of V. fischeri P-0 exposure to ethidium bromide. The substance had no effect on the following bacterial species: Aeromonas liquefaciens 301, Achromobacter liquefaciens, Pseudomonas putida 15, Pseudomonas fluorescence 7, Escherichia coli AH-32 and Sphaphylococcus aureus.