Effects of aspirin and paracetamol on ATPases of human fetal brain: an in vitro study
Sarkar, A.K.; Chakraborti, A.; Saha, U.K.; Bose, S.K.; Sengupta, D.
Indian Journal of Experimental Biology 27(9): 802-804
1989
ISSN/ISBN: 0019-5189 PMID: 2561117 Document Number: 331730
In vitro effects of aspirin and paracetamol at the doses 200, 400, 600, 800 nmole/mg protein on ATPases activity were studied in the cerebrum and cerebellum of human fetus covering the age range from 10 weeks to 32 weeks of gestation. Both aspirin and paracetamol inhibit Na+K+ ATPase and Mg2+ ATPase in a dose dependent manner. The inhibition of Na+K+ ATPase and Mg2+ ATPase activity which may affect the release and uptake of biogenic amines in CNS, hinders the maturation of human fetal brain.