Effect of lead acetate administration on ATPases of brain and its mitochondrial and synaptosomal fractions in adult mice
Bansal, M.R.; Kaushal, N.
Journal of Environmental Pathology Toxicology and Oncology Official Organ of the International Society for Environmental Toxicology and Cancer 9(5-6): 411-416
1989
ISSN/ISBN: 0731-8898 PMID: 2561605 Document Number: 330114
The effects of oral administration of lead acetate on the activities of cation-transport ATPases and on the brain and its mitochondrial and synaptosomal fractions of male mice were studied at doses of 1, 5, and 20 mg lead acetate per 100 g body weight per day for 4, 8, 12, and 16 weeks. The activities of Na(+)-ATPase, K(+)-ATPase, total-ATPase, and Na(+)-K(+)-ATPase decreased significantly at doses of 1 and 5 mg lead acetate after 12 and 16 weeks of treatment; changes in the activities were not marked after 4 and 8 weeks of lead administration. However, the 20-mg dose significantly reduced enzyme activities at all treatment intervals.