Pharmacokinetic interactions of penicillamine in rheumatoid arthritis
Seideman, P.; Lindström, B.
Journal of Rheumatology 16(4): 473-474
1989
ISSN/ISBN: 0315-162X PMID: 2664169 Document Number: 330688
The pharmacokinetic effect of the combined treatment of penicillamine with indomethacin and chloroquine was investigated in patients with rheumatoid arthritis. The mean plasma penicillamine concentration increased by 26% during indomethacin and 34% during chloroquine treatment. This new pharmacokinetic interaction may have important clinical implications.
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