Pharmacokinetic interactions of penicillamine in rheumatoid arthritis

Seideman, P.; Lindström, B.

Journal of Rheumatology 16(4): 473-474

1989


ISSN/ISBN: 0315-162X
PMID: 2664169
Document Number: 330688
The pharmacokinetic effect of the combined treatment of penicillamine with indomethacin and chloroquine was investigated in patients with rheumatoid arthritis. The mean plasma penicillamine concentration increased by 26% during indomethacin and 34% during chloroquine treatment. This new pharmacokinetic interaction may have important clinical implications.

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