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Head activator acts as an autocrine growth factor for NH15-CA2 cells in the G2/mitosis transition

Schaller, H.C.; Druffel-Augustin, S.; Dübel, S.

EMBO Journal 8(11): 3311-3318

1989

ISSN/ISBN: 0261-4189
PMID: 2583101
Document Number: 328913
The neuropeptide head activator (HA) acts as an autocrine growth factor for the neural cell line NH15-CA2. Cell proliferation is increased in the presence of HA and inhibited by HA peptide-specific antisera. Stimulation of cellular proliferation is visible 2 h after HA application as an increase in cells in mitosis. HA has no direct effect on stimulating DNA synthesis. HA thus functions as a control signal in the G2/mitosis transition and not in the G1/S transition. Receptors for HA are present on small round cells in clusters of foci and not on cells with differentiated morphology, suggesting cell-cycle-dependent HA receptor expression.

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