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On the autocrine growth regulation of Morris hepatoma cells

Guzik, K.; Klein, A.

Folia Histochemica et Cytobiologica 27(4): 209-217

1989

ISSN/ISBN: 0239-8508
PMID: 2635673
Document Number: 328321
Chemically induced, transplantable Morris hepatoma 7777 cells (MH) were examined for their anchorage-dependent and anchorage-independent growth properties. MH cells were found to grow on solid surface in a density-dependent manner, with respect to serum factors and gelatinization. The correlation between anchorage independent growth of MH cells and agar or serum concentrations in the culture medium was described. The ability of MH cells to stimulation of soft agar colony formation of NRK-49F indicator cells in coculture assay was presented. Autocrine control of proliferation of MH cells by TGFs-like factor(s) was suggested.

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